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Polycyclic aromatic hydrocarbon degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
4-Hydroxyphthalate <=> 3-hydroxybenzoate + CO2 4.1.1.55 4,5-dihydroxyphthalate decarboxylase
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9,10-Dihydroxyanthracene <=> anthraquinone + 2 H+ not assigned
 –
cis-4,5-Dihydroxy-4,5-dihydropyrene + NAD+ <=> 4,5-dihydroxypyrene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
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1-Formyl-2-indanone + H2O <=> 2-indanone + CO2 + 2 H+ + 2 e- not assigned
 –
1-Hydroxypyrene-7,8-oxide <=> 1,8-dihydroxypyrene not assigned
 –
phenanthrene + NADH + H+ + O2 <=> (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD+ 1.13.11
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1-hydroxy-2-naphthoate + NADH + O2 + H+ <=> 1,2-dihydroxynaphthalene + NAD+ + H2O + CO2 1.14.13.1 salicylate 1-monooxygenase
1.14.13.135 1-hydroxy-2-naphthoate hydroxylase
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1-phenanthrol + CH3-R <=> 1-Methoxyphenanthrene + R 2.1.1
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O2 + 1-hydroxy-2-naphthoate <=> H+ + (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 1.13.11.38 1-hydroxy-2-naphthoate 1,2-dioxygenase
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pyrene + O2 <=> cis-4,5-Dihydroxy-4,5-dihydropyrene 1.14
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2-Hydroxy-2H-benzo[h]chromene-2-carboxylate <=> cis-4-(1''-Hydroxynaphth-2''-yl)-2-oxobut-3-enoate 5.1.2
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2 1-Indanone + O2 + 2 NADH + 2 H+ <=> 2 3-hydroxy-1-indanone + 2 NAD+ 1.14.12
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2-Hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene)-but-2-enoic_acid + H2O <=> 2-Formyl-1-indanone + pyruvate not assigned
 –
benzo[a]pyrene + O2 + NADH + H+ <=> Benzo[a]pyrene-cis-7,8-dihydrodiol + NAD+ 1.14.12
–
2,3-dihydroxynaphthalene <=> salicylate not assigned
 –
4-(3-Hydroxy-2-naphthyl)-2-oxobut-3-enoic_acid <=> 6,7-Benzocoumarin not assigned
 –
H+ + 3,4-dihydroxyphthalate <=> CO2 + 3,4-dihydroxybenzoate 4.1.1.69 3,4-dihydroxyphthalate decarboxylase
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4-(3-Hydroxy-2-naphthyl)-2-oxobut-3-enoic_acid + 2 H2O <=> 3-hydroxy-2-naphthoate + pyruvate not assigned
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melilotate + ATP + CoA + FAD + NAD+ <=> salicylate + AMP + diphosphate + FADH2 + acetyl-CoA + NADH + H+ not assigned
 –
1,2-Dihydroxyfluorene + O2 <=> 2-Hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene)but-2-enoic_acid 1.13.11
–
trans-9(S),10(S)-Dihydrodiolphenanthrene <=> 9-Phenanthrol + H2O not assigned
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3-hydroxy-2-naphthoate <=> 2,3-dihydroxynaphthalene not assigned
 –
Pyrene-1,2-oxide <=> 1-hydroxypyrene not assigned
 –
fluorene + O2 + 2 H+ <=> 3,4-Dihydroxyfluorene not assigned
 –
NAD+ + (+)-cis-3,4-dihydrophenanthrene-3,4-diol <=> H+ + NADH + 3,4-Dihydroxyphenanthrene 1.3.1.49 cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase
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benzo[a]pyrene + O2 + NADH + H+ <=> Benzo[a]pyrene-cis-4,5-dihydrodiol + NAD+ 1.14.12
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Pyrene-4,5-dione <=> Phenanthrene-4,5-dicarboxylate 1.6
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O2 + 3,4-dihydroxybenzoate <=> H+ + 3-carboxy-cis,cis-muconate 1.13.11.3 protocatechuate 3,4-dioxygenase
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1-Hydroxy-6-methoxypyrene + CH3-R <=> 1,6-Dimethoxypyrene + R 2.1.1
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2 2-indanone + O2 + 2 NADH + 2 H+ <=> 2 3-isochromanone + 2 NAD+ 1.14.12
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anthracene + O2 + 2 H+ + 2 e- <=> Anthracene-9,10-dihydrodiol 1.14
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9-fluorenone + NADH + H+ + O2 <=> 1,1a-dihydroxy-1-hydrofluoren-9-one + NAD+ 1.14.12
1.14.12.22 carbazole 1,9a-dioxygenase
–
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pyrene + O2 <=> Pyrene-1,2-oxide + H2O 1.14
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Benzo[a]pyrene-cis-11,12-dihydrodiol <=> 11,12-Dihydroxybenzo[a]pyrene 1.3
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1-Indanone + NADPH + H+ + O2 <=> dihydrocoumarin + NADP+ + H2O 1.14.12
1.14.13.84 4-hydroxyacetophenone monooxygenase
1.14.13.92 phenylacetone monooxygenase
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–
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1-hydroxy-2-naphthaldehyde + NAD+ + H2O <=> 1-hydroxy-2-naphthoate + NADH + H+ 1.2.1
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9-fluorenol + NAD+ <=> 9-fluorenone + NADH + H+ 1.1.1.112 indanol dehydrogenase
1.1.1.256 fluoren-9-ol dehydrogenase
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3-hydroxybenzoate + O2 + NADPH + H+ <=> 3,4-dihydroxybenzoate + H2O + NADP+ 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.23 3-hydroxybenzoate 4-monooxygenase
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1,2-Dihydroxyanthracene + O2 <=> 4-(3-Hydroxy-2-naphthyl)-2-oxobut-3-enoic_acid 1.13.11
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1,2-Dihydrophthalic_acid + NAD+ <=> Phthalate + NADH + H+ 1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
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(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O <=> 2-carboxybenzaldehyde + pyruvate 4.1.2.34 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
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1-hydroxypyrene <=> pyren-1-yl_sulfate 2.8.2
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9-fluorenol + NADP+ <=> 9-fluorenone + NADPH + H+ 1.1.1.112 indanol dehydrogenase
1.1.1.256 fluoren-9-ol dehydrogenase
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phenanthrene + O2 + NADH + H+ <=> phenanthrene-9,10-oxide + H2O + NAD+ 1.14.13
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4,5-dihydroxypyrene + O2 <=> Phenanthrene-4,5-dicarboxylate 1.13.11
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9,10-dihydroxy-benzo(a)pyrene + O2 <=> cis-4-(8-Hydroxypyren-7-yl)-2-oxobut-3-enoate 1.13.11
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fluorene + O2 + 2 H+ <=> 1,2-Dihydroxyfluorene not assigned
 –
cis-4-(7-Hydroxtpyren-8-yl)-2-oxobut-3-enoate <=> 7,8-Dihydropyrene-8-carboxylate not assigned
 –
Phenanthrene-1,2-oxide <=> 1-phenanthrol not assigned
 –
H+ + Phthalate + O2 + NADH <=> Phthalate_3,4-cis-dihydrodiol + NAD+ 1.14.12
–
Benzo[a]pyrene-trans-11,12-dihydrodiol <=> 11,12-Dihydroxybenzo[a]pyrene 1.3
–
phenanthrene-9,10-oxide <=> 9-Phenanthrol not assigned
 –
Benzo[a]pyrene-11,12-epoxide + H2O <=> Benzo[a]pyrene-trans-11,12-dihydrodiol 3.3.2
–
cis-3,4-Phenanthrenedihydrodiol-4-carboxylate <=> 3,4-Dihydroxyphenanthrene + CO2 1.3
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Anthracene-9,10-dihydrodiol <=> 9,10-Dihydroxyanthracene + 2 H+ 1.1
–
1-Methoxypyrene-6,7-oxide <=> 1-Hydroxy-6-methoxypyrene not assigned
 –
cis-4-(8-Hydroxypyren-7-yl)-2-oxobut-3-enoate <=> 7,8-Dihydropyrene-7-carboxylate not assigned
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cis-4-(8-Hydroxypyren-7-yl)-2-oxobut-3-enoate <=> 10-Oxabenzo[def]chrysen-9-one + formate 4.1.3
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O2 + 3,4-dihydroxybenzoate <=> H+ + 4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde 1.13.11.8 protocatechuate 4,5-dioxygenase
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Phthalate + O2 + NADH + H+ <=> cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ 1.14.12.7 phthalate 4,5-dioxygenase
–
1-hydroxypyrene + O2 <=> 1-Hydroxypyrene-7,8-oxide + H2O 1.14
–
4,5-Chrysenedicarboxylate <=> 4-Chrysenecarboxylate + CO2 4.1.1
–
2-Hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene)but-2-enoic_acid + H2O <=> 1-Formyl-2-indanone + pyruvate not assigned
 –
fluorene + O2 + NADH + H+ <=> (3S,4R)-cis-3,4dihydroxy-3,4-dihydrofluorene + NAD+ 1.14.12
1.14.12.12 naphthalene 1,2-dioxygenase
–
–
benzo(a)pyrene-9,10-dihydrodiol + NAD+ <=> 9,10-dihydroxy-benzo(a)pyrene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
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3,4-Dihydroxy-3,4-dihydro-9-fluorenone <=> 4-Hydroxy-9-fluorenone + H2O not assigned
 –
1-hydroxy-2-naphthaldehyde + pyruvate <=> (3E)-4-(1-hydroxynaphthalen-2-yl)-2-oxobut-3-enoate + H2O 4.1.2
4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
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2 1-Indanone + O2 + 2 NADPH + 2 H+ <=> 2 3-hydroxy-1-indanone + 2 NADP+ 1.14.12
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Phenanthrene-4-carboxylate + O2 + NADH + H+ <=> cis-3,4-Phenanthrenedihydrodiol-4-carboxylate + NAD+ 1.14.12
–
2 1-Indanone + 2 CO2 <=> 2 2-Formyl-1-indanone + O2 not assigned
 –
Pyrene-4,5-dione + NADH + H+ <=> 4,5-dihydroxypyrene + NAD+ 1.6.5
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1,1a-dihydroxy-1-hydrofluoren-9-one + H2O <=> 2,3-Dihydroxy-2''-carboxybiphenyl + 2 H+ 1.3
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4,5-Chrysenedicarboxylate <=> 5-Chrysenecarboxylate + CO2 4.1.1
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Benzo[a]pyrene-cis-7,8-dihydrodiol + O2 <=> cis-4-(7-Hydroxtpyren-8-yl)-2-oxobut-3-enoate not assigned
 –
H2O + dihydrocoumarin <=> H+ + melilotate 3.1.1.25 1,4-lactonase
3.1.1.35 dihydrocoumarin hydrolase
–
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2-indanone + NADPH + H+ + O2 <=> 3-isochromanone + NADP+ + H2O 1.14.12
1.14.13.84 4-hydroxyacetophenone monooxygenase
–
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1-hydroxypyrene + O2 <=> 1-Hydroxypyrene-6,7-oxide + H2O 1.14
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1,2-Dihydroxyanthracene <=> 1-Methoxy-2-hydroxyanthracene not assigned
 –
Phenanthrene-4,5-dicarboxylate <=> Phenanthrene-4-carboxylate + CO2 4.1.1
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terephthalate + O2 + NADH + H+ <=> (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ 1.14.12.15 terephthalate 1,2-dioxygenase
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2,3-Dihydroxy-2''-carboxybiphenyl + O2 <=> 2-Hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate 1.13
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pyrene + O2 <=> Pyrene-4,5-oxide + H2O 1.14
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1-Methoxypyrene + O2 <=> 1-Methoxypyrene-6,7-oxide + H2O 1.14
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benzo[a]pyrene + O2 + NADH + H+ <=> benzo(a)pyrene-9,10-dihydrodiol + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
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2 1-Indanone + O2 + 2 NADH + 2 H+ <=> 2 dihydrocoumarin + 2 NAD+ 1.14.12
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anthracene + NADH + H+ + O2 <=> cis-Anthracene_dihydrodiol + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
–
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benzo[a]pyrene + NADH + H+ + O2 <=> Benzo[a]pyrene-cis-11,12-dihydrodiol + NAD+ 1.14.12
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phenanthrene + O2 + NADH + H+ <=> Phenanthrene-1,2-oxide + H2O + NAD+ 1.14.13
–
Pyrene-4,5-oxide + H2O <=> trans-4,5-Dihydroxy-4,5-dihydropyrene 3.3.2
–
1,8-dihydroxypyrene <=> 1,8-pyrenequinone not assigned
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1-hydroxypyrene + S-adenosyl-L-methionine <=> 1-Methoxypyrene + S-adenosyl-L-homocysteine 2.1.1
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2-carboxybenzaldehyde + NAD+ + H2O <=> Phthalate + NADH + H+ 1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.78 2-formylbenzoate dehydrogenase
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–
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polyethylene_terephthalate + H2O <=> polyethylene_terephthalate + mono(2-hydroxyethyl)_terephthalate 3.1.1.101 poly(ethylene terephthalate) hydrolase
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H+ + 4,5-Dihydroxyphthalate <=> CO2 + 3,4-dihydroxybenzoate 4.1.1.55 4,5-dihydroxyphthalate decarboxylase
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benzo[a]pyrene + O2 <=> Benzo[a]pyrene-11,12-epoxide 1.14
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H+ + salicylate + O2 + NADH <=> catechol + CO2 + H2O + NAD+ 1.14.13.1 salicylate 1-monooxygenase
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cis-Anthracene_dihydrodiol + NAD+ <=> 1,2-Dihydroxyanthracene + NADH 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
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phenanthrene + O2 + NADH + H+ <=> 1-phenanthrol + H2O + NAD+ 1.14.13
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4,5-Dihydroxybenzo[a]pyrene + O2 <=> 4,5-Chrysenedicarboxylate 1.13.11
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Benzo[a]pyrene-cis-4,5-dihydrodiol <=> 4,5-Dihydroxybenzo[a]pyrene 1.3
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(3S,4R)-cis-3,4dihydroxy-3,4-dihydrofluorene <=> 3,4-Dihydroxyfluorene + 2 H+ 1.3.1
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3-isochromanone <=> catechol not assigned
 –
3-hydroxy-2-naphthoate + O2 <=> 3-[6-(Carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate 1.13.11
–
1-Hydroxypyrene-6,7-oxide <=> 1,6-dihydroxypyrene not assigned
 –
fluorene + O2 + NADH + H+ <=> 9-fluorenol + H2O + NAD+ 1.14.12
1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
1.14.13
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1,6-dihydroxypyrene <=> 1,6-pyrenequinone not assigned
 –
4,5-dihydroxypyrene <=> Pyrene-4,5-dione not assigned
 –
9-fluorenone + O2 + 2 NADH <=> 3,4-Dihydroxy-3,4-dihydro-9-fluorenone + 2 NAD+ 1.14.12
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9-fluorenone + O2 + 2 NADPH <=> 3,4-Dihydroxy-3,4-dihydro-9-fluorenone + 2 NADP+ 1.14.12
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3-[6-(Carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate <=> 1,2-Dihydrophthalic_acid not assigned
 –
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ <=> 4,5-Dihydroxyphthalate + NADH + H+ 1.3.1.64 phthalate 4,5-cis-dihydrodiol dehydrogenase
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2-Hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O <=> Phthalate + 2-hydroxy-2,4-pentadienoate 3.7.1
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3,4-Dihydroxyfluorene + O2 <=> 2-Hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene)-but-2-enoic_acid 1.13.11
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(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ <=> 3,4-dihydroxybenzoate + CO2 + NADH 1.3.1.53 (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
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1,2-Dihydroxyanthracene + O2 <=> 3-(2-Carboxyvinyl)naphthalene-2-carboxylic_acid 1.13.11
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phenanthrene-9,10-oxide + H2O <=> trans-9(S),10(S)-Dihydrodiolphenanthrene 3.3.2
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3,4-Dihydroxyphenanthrene + O2 <=> 2-Hydroxy-2H-benzo[h]chromene-2-carboxylate 1.13.11
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Phthalate_3,4-cis-dihydrodiol + NAD+ <=> 3,4-dihydroxyphthalate + NADH + H+ 1.3.1
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mono(2-hydroxyethyl)_terephthalate + H2O <=> terephthalate + ethylene_glycol + H+ 3.1.1.102 mono(ethylene terephthalate) hydrolase
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